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FLASH GENE

Symbol

TEAD1

contributors: mct - updated : 06-03-2019

HGNC name	TEA domain family member 1 (SV40 transcriptional enhancer factor)
HGNC id	11714

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

AA , AIC2

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in hepatocellular carcinoma (HCC), and overexpression is involved in the growth and differentiation of HCC tumoral         suppressed multiple malignant phenotypes of osteosarcoma cells including cell proliferation, apoptosis resistance, and invasive potential

Susceptibility

Variant & Polymorphism

Candidate gene	prostate basal cell marker that correlate with poor clinical outcome in prostate cancer
Marker
Therapy target

ANIMAL & CELL MODELS

	transgenic mice overexpressing TEAD1 showed an age-dependent heart dysfunction
	homozygous mutant mice embryos with a targeted disruption of the TEAD1 gene displayed abnormal heart development and died between embryonic days 11 and 12
	murine Tead1-deficient cardiomyocytes have significantly decreased proliferation during the immediate postnatal period, when proliferation rate is normally high