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FLASH GENE
Symbol PLCB2 contributors: mct - updated : 11-07-2013
HGNC name phospholipase C, beta 2
HGNC id 9055
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --low  
suppression of PLCB2 plays an important role in switching M1 macrophages into an M2-like state
constitutional       loss of function
loss of PLCB2 and PLCB3 significantly impaired T cell migration
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • may constitute a molecular marker of breast tumor cells able to monitor the progression to invasive cancers
  • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    target for novel therapeutic breast cancer strategies
    ANIMAL & CELL MODELS