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FLASH GENE
Symbol PLCB2 contributors: mct - updated : 11-07-2013
HGNC name phospholipase C, beta 2
HGNC id 9055
DNA
TYPE functioning gene
STRUCTURE 20.08 kb     32 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
RNA
TRANSCRIPTS type messenger
text presence of transcripts of two forms of PLCB2 generated by alternative splicing (PMID: 17497434)
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
32 - 4694 - 1185 . expressed in platelets at the protein level . higher cytoplasmic to nuclear ratio for PLCB2b compared to PLCB2a, suggesting that a great proportion of the total PLCB2a was in the nucleus relative to PLB2b 2007 17497434
  • PLCB2a
  • - splicing - - 1170 . expressed in platelets at the protein level . higher cytoplasmic to nuclear ratio for PLCB2b compared to PLCB2a, suggesting that a great proportion of the total PLCB2a was in the nucleus relative to PLB2b 2007 17497434
  • lacking 15 AAs (corresponding to 864-878)
  • EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node    
     spleen    
     tonsils    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow    Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte Homo sapiens
    Blood/Hematopoieticplatelet Homo sapiens
    cell lineage predominantly, in hematopoietic cells
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic
    text
  • WDR26 is required for PLCB2 translocation from the cytosol to the membrane in polarized leukocytes
  • basic FUNCTION
  • phospholipase C, beta 2, phosphatidylinositol specific
  • catalyzing the hydrolysis of phosphatidylinositol 4,5 biphosphate to generate diacylglycerol and inositol 1,4,5 triphosphate
  • mediating a wide variety of cellular stimuli, critical to many chemoattractant elicited responses
  • in differentiating cells, the association of PLCB2 with actin, mediated by the PH domain, seems crucial for catalytic activity
  • plays a pivotal role in G-protein dependent signal transduction in platelets
  • PLCB2, PLCB3 play a critical role in T lymphocyte chemotaxis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds strongly to PLCdelta1(PLCD1) and inhibits its catalytic activity
  • activity of PLCD1 is controlled by the amount of bound PLCB2 that changes with displacement of the enzyme by heterotrimeric or small G proteins
  • WDR36 associated with PLCB2 and increased the interaction between GNAQ and PLCB2, but prevented sequestration of activated GNAQ by GRK2
  • interaction between SLC9A3R1 and CXCR2 or PLCB2 is PDZ motif-dependent
  • WDR26 is required for PLCB2 translocation from the cytosol to the membrane in polarized leukocytes, and the translocation of PLCB2 was sufficient to cause partial activation of PLCB2
  • cell & other
    REGULATION
    activated by RAC1, that can activate PLCB2 to increase intracellular Ca(2+) levels
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    suppression of PLCB2 plays an important role in switching M1 macrophages into an M2-like state
    constitutional       loss of function
    loss of PLCB2 and PLCB3 significantly impaired T cell migration
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • may constitute a molecular marker of breast tumor cells able to monitor the progression to invasive cancers
  • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    target for novel therapeutic breast cancer strategies
    ANIMAL & CELL MODELS