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	HGNC	UniGene	Nucleotide	OMIM		UCSC

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FLASH GENE

Symbol

CACNA1C

contributors: mct/npt/pgu - updated : 20-11-2015

HGNC name	calcium channel, voltage-dependent, L type, alpha 1C subunit
HGNC id	1390

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

TMTS , BRGS3

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in esophageal squamous cell carcinoma (ESCC)

Susceptibility

to bipolar disorder, and schizophrenia

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cardiovascular     testosterone binding to CACNA1C, thereby supporting its beneficial role as an endogenous Ca2+ channel antagonist in the treatment of cardiovascular disease

ANIMAL & CELL MODELS

mice expressing CACNA1C channels with the distal C terminus deleted (DCT-/-) develop cardiac hypertrophy and die prematurely after E15