Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CACNA1C contributors: mct/npt/pgu - updated : 20-11-2015
HGNC name calcium channel, voltage-dependent, L type, alpha 1C subunit
HGNC id 1390
DNA
TYPE functioning gene
STRUCTURE 727.16 kb     47 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
cytosine-phosphate-guanine/HTF
text structure
  • DNA methylation status on the CpG island shore of Cacna1c may have an important role in transcript regulation
  • MAPPING cloned Y linked Y status confirmed
    Map pter - D12S100 - D12S1117 - D12S1094 - D12S1113 - D12S1689 - D12S381E - D12S1694 - D12S2051 - (D12S2052 , D12S1108 ) - D12S1116 - D12S1096 - D12S2044 - D12S2049 - (D12S1615 , D12S1443 , CACNA1C ) - D12S1664 - (D12S1626 , D12S1403 ) - (D12S372 , D12S1062 ) - (D12S1866 , D12S1077 , D12S1315 )- D12S1467 - D12S1050 - cen
    Authors 4st Workshop chrom.12 (97)
    RNA
    TRANSCRIPTS type messenger
    text many alternate transcriptional splice variants
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    47 - 13480 239.51 2138 - 2008 19065143
    variant 18 or HLCC70
    49 - 13624 245 2186 - 2008 19065143
    HLCC90
    47 - 13603 243.6 2179 - 2008 19065143
    variant 3 or HLCC126
    48 - 13585 - 2173 - 2008 19065143
    variant 4 or HLCC85
    48 - 13564 - 2166 - 2008 19065143
    variant 5 or HLCC88
    48 - 13540 - 2158 - 2008 19065143
    variant 6 or HLCC87
    47 - 13537 - 2157 - 2008 19065143
    47 - 13537 - 2157 - 2008 19065143
    variant 8 or HLCC71
    47 - 13537 - 2157 - 2008 19065143
    variant 9or HLCC72
    47 - 13531 - 2155 - 2008 19065143
    variant 10 or HLCC89
    46 - 13504 - 2146 - 2008 19065143
    variant 11 or HLCC73
    46 - 13504 - 2146 - 2008 19065143
    variant 12 or HLCC74
    46 - 13498 - 2144 - 2008 19065143
    variant 13 or HLCC125
    47 - 13480 - 2138 - 2008 19065143
    47 - 13480 - 2138 - 2008 19065143
    variant 15 or HLCC69
    47 - 13480 - 2138 - 2008 19065143
    variant 16 or HLCC78
    47 - 13480 - 2138 - 2008 19065143
    variant 17 or HLCC77
    47 - 13471 239 2135 - 2008 19065143
    46 - 13447 238 2127 - 2008 19065143
    variant 20 or HLCC76
    50 - 13729 249 2221 - 2008 19065143
    48 - 13585 - 2173 - 2008 19065143
    47 - 13480 - 2138 - 2008 19065143
    47 - 13660 - 2198 - 2008 19065143
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Endocrinepancreas    
    Lymphoid/Immunespleen   highly
    Nervousbrain    
    Reproductivefemale systemuterus  highly
     male systemtestis  highly
     male systemprostate   
    Skin/Tegumentskin appendageshairfollicle   Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumcardiac  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Endocrineislet cell (alpha,beta...)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminus is important for the regulation of voltage-dependent inactivation (VDI)by CABP1
  • four domains of homology
  • a PDZ-binding motif at its cytosolic tail
  • six alpha helical membrane spanning segments (24 transmembrane segments)
  • distal C-terminus (approximately residues 1650-1950) with an important, predominantly inhibitory domain, specific for the heart channel, and containing sites for the SH2 and SH3 binding of Src kinase
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to rattus cacna1c
    ortholog to murine Cacna1c
    Homologene
    FAMILY
  • calcium channel alpha-1 subunit family
  • Enigma subfamily of the PDZ-LIM domain protein family
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text colocalized with CABP1 in somatodendritic areas of neurons in the brain
    basic FUNCTION
  • calcium voltage-gated channel (VDCC), L type
  • playing an important role in excitation-contraction coupling in the heart
  • in iron transport into cardiomyocytes under iron-overloaded conditions
  • role of voltage-gated Ca2+ channels in nonexcitable cells during development (PMID;
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
  • CACNA1C targeting to BIN1 is functionally important to cardiac calcium signaling
  • AKAP7 interacts with neuronal CACNA1C via their C terminus
  • serine 1884 is essential for the regulation of CACNA1C by PRKD1
  • interaction between LDB3 and CACNA1C, that facilitated PRKA-mediated phosphorylation of the CACNA1C at Ser1928
  • ADRA1B contraction of vascular smooth muscle involves activation of PLD1, which controls a portion of the ADRA1B-induced CACNA1C channel activity
  • expression of CACNA1C mRNA was rhythmic (peaking during the late night) and regulated by the circadian clock component NR1D1
  • HAP1 is important for insulin secretion of pancreatic beta-cells via regulating the intracellular trafficking and plasma membrane localization of CACNA1C, providing new insight into the mechanisms that regulate insulin release from pancreatic beta cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) TMTS , BRGS3
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in esophageal squamous cell carcinoma (ESCC)
    Susceptibility to bipolar disorder, and schizophrenia
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cardiovascular  
    testosterone binding to CACNA1C, thereby supporting its beneficial role as an endogenous Ca2+ channel antagonist in the treatment of cardiovascular disease
    ANIMAL & CELL MODELS
  • mice expressing CACNA1C channels with the distal C terminus deleted (DCT-/-) develop cardiac hypertrophy and die prematurely after E15