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FLASH GENE

Symbol

NPPA

contributors: mct/npt - updated : 12-01-2018

HGNC name	natriuretic peptide precursor A
HGNC id	7939

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

ATFB6 , ATRST2

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in congestive heart failure

Susceptibility

to nephropathy and microvascular damage in type 1 diabetes to blood pressure variation development of ischemic stroke to cardioembolic stroke

Variant & Polymorphism other	polymorphism 2238C affect the course of nephropathy in inadequately controlled type 1 diabetic patients
	common genetic variants at the NPPA-NPPB locus found to be associated with circulating natriuretic peptide concentrations contribute to interindividual variation in blood pressure and hypertension (Newton-Cheh 2009)
	association between frequent nonsynonymous variant of NPPA and cardioembolic stroke
	NPPA genetic polymorphism and serum NPPA levels may contribute to the development of ischemic stroke

Candidate gene
Marker	NPPA genetic polymorphism and serum NPPA levels could be potential biomarkers for early detection of ischemic stroke
	marker of heart failure in children with left ventricular volume overload
Therapy target

ANIMAL & CELL MODELS

pregnant corin- or Nppa-deficient mice developed high blood pressure and proteinuria, characteristics of pre-eclampsia