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Symbol NPPA contributors: mct/npt - updated : 12-01-2018
HGNC name natriuretic peptide precursor A
HGNC id 7939
corresponding disease(s) ATFB6 , ATRST2
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --over  
in congestive heart failure
  • to nephropathy and microvascular damage in type 1 diabetes
  • to blood pressure variation
  • development of ischemic stroke
  • to cardioembolic stroke
  • Variant & Polymorphism other
  • polymorphism 2238C affect the course of nephropathy in inadequately controlled type 1 diabetic patients
  • common genetic variants at the NPPA-NPPB locus found to be associated with circulating natriuretic peptide concentrations contribute to interindividual variation in blood pressure and hypertension (Newton-Cheh 2009)
  • association between frequent nonsynonymous variant of NPPA and cardioembolic stroke
  • NPPA genetic polymorphism and serum NPPA levels may contribute to the development of ischemic stroke
  • Candidate gene
  • NPPA genetic polymorphism and serum NPPA levels could be potential biomarkers for early detection of ischemic stroke
  • marker of heart failure in children with left ventricular volume overload
  • Therapy target
  • pregnant corin- or Nppa-deficient mice developed high blood pressure and proteinuria, characteristics of pre-eclampsia