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FLASH GENE

Symbol

PKM

contributors: mct/npt/pgu - updated : 03-09-2016

HGNC name	pyruvate kinase, muscle
HGNC id	9021

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in gastric cancer tumoral     --over   with MYC, PTBP1, HNRNPA1 and HNRNPA2B1 in gliomas, correlated with PKM2 expression tumoral     --over   in a grade-specific manner in human glioma

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	PKM/TRIM35 expression could be a biomarker for the prognosis of hepatocellular carcinoma (HCC)
Therapy target
	System Type Disorder Pubmed cancer     because most normal tissues express an isoform of pyruvate kinase other than PKM2, selective targeting of PKM2 provides an opportunity to target cell metabolism for cancer therapy

ANIMAL & CELL MODELS