| protein
| binds directly and selectively to tyrosine-phosphorylated peptides |
|
OPA protein |
|
interacting with HNRNPA2B1, PTBP1, and HNRNPA1 (have critical role in promoting PKM2 production in tumours, and overexpression of some combination of them is, like PKM2 expression, likely to be a general phenomenon in cancer  |
|
interaction with PKM2, and inhibition of PKM2 by PRL contributes potentially to the PRL-stimulated cell proliferation |
|
SAICAR stimulates PKM and promotes cancer cell survival in glucose-limited conditions |
|
KDM8/PKM interaction resides at the intersubunit interface region of PKM, which hinders PKM tetramerization and blocks pyruvate kinase activity |
|
ZBTB7A directly binds to the promoter and represses the transcription of critical glycolytic genes, including SLC2A3, PFKP, and PKM |
|
TRIM35 interacts with PKM and the coiled-coil domain is required for such an interaction |
|
ECM1 plays an important role in promoting the Warburg effect mediated by PKM |
|
TRIM35 inhibits phosphorylation of pyruvate kinase isoform M2 (PKM), which is involved in aerobic glycolysis of cancer cells |
|
TGM2 interacts with PKM, a rate limiting enzyme of glycolysis which is responsible for maintaining a glycolytic phenotype in malignant cells and displays non metabolic functions, including transcriptional co-activation and protein kinase activity |
|
PKM activates MTOR signaling through phosphorylating MTOR inhibitor AKT1 substrate 1 (AKT1S1) |
