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FLASH GENE
Symbol CCL4 contributors: mct - updated : 06-05-2020
HGNC name chemokine (C-C motif) ligand 4
HGNC id 10630
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --over  
in CD8+ cells and CD4+ cells in sarcoidosis
Susceptibility
  • to AIDS
  • Variant & Polymorphism SNP influencing HIV Type 1 transmission and AIDS disease progression (Omim: 609423)
    Candidate gene
    Marker
  • variations in the CCL4 gene may help to predict breast cancer progression and metastasis
  • decreased preclinical CCL3 and CCL4 levels might be associated with a subsequently increased risk of nasopharyngeal carcinoma
  • CCL4 rs10491121 may be a factor to predict the tumor size in oral squamous cell carcinoma (OSCC) patients
  • Therapy target
    ANIMAL & CELL MODELS