| basic FUNCTION
| monocyte, chemoattractant, activated T cell and dendritic cell |
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one of the major HIV-suppressive factors produced by CD8+ T cells |
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playing a role in etablishement of cell polarity |
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contributing to intracellular signaling and other chemokine receptor function |
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promote trophoblast migration at the feto-maternal interface  |
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with CCL3, may directly or indirectly affect neuronal excitability, and are implicated in the etiology and pathogenesis of temporal lobe epilepsy |
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principal regulator of macrophage migration and signals through CCR5 |
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crucial role of CCL4 in the development of dry eye syndrome in CF patients and immunopathogenesis of ocular surface changes in this disease |
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CCL3 and CCL4 are chemokines crucial for immune responses towards infection and inflammation |
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AR-CCL4-STAT3 axis is key regulator during prostate tumor initiation, suggesting important roles of infiltrating macrophages and inflammatory cytokines for the prostate tumorigenesis |
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Tregs produced both CCL3 and CCL4 in response to stimulation, and production of these chemokines was critical for migration of target T cells |
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macrophage-derived foam cells impair endothelial barrier function by inducing endothelial-mesenchymal transition via CCL4 |
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can promote tumor development and progression by recruiting regulatory T cells and pro-tumorigenic macrophages, and acting on other resident cells present in the tumor microenvironment, such as fibroblasts and endothelial cells, to facilitate their pro-tumorigenic capacities |
