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FLASH GENE

Symbol

CYBA

contributors: npt/ - updated : 07-05-2007

HGNC name	cytochrome b-245, alpha polypeptide
HGNC id	2577

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

CYBA

related resource

Autosomal recessive chronic granulomatous disease (CGD) deficiency of p22phox CYBAbase

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in endothelial cells (Goettsch 2009)

Susceptibility

to coronary atherosclerosis to non-Hodgkin lymphoma (NHL) to obstructive pulmonary disease

Variant & Polymorphism SNP	significantly associated with an increased overall risk of NHL
	-930AG+GG were significantly over-represented in chronic obstructive pulmonary disease (Vibhuti 2010)

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS