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FLASH GENE

Symbol

MMP13

contributors: mct/npt/pgu - updated : 27-03-2016

HGNC name	matrix metalloproteinase 13 (collagenase 3)
HGNC id	7159

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

SEMD2 , MAND2

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in breast carcinoma, squamous cell carcinomas of head and neck and vulvar squamous cell carcinoma constitutional     --over   overexpressed in rheumatoid arthritis and inabdominal aortic aneurysm tumoral     --over   in renal cell carcinoma bone metastasis and is induced by TGF-beta1

Susceptibility

to coronary artery disease

Variant & Polymorphism other	MMP13 intron polymorphism rs640198 is associated with the severity of coronary artery disease

Candidate gene	for SEMD2
Marker	could be a potential prognostic marker for colorectal cancer patients
Therapy target

ANIMAL & CELL MODELS