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FLASH GENE

Symbol

NR1H2

contributors: mct - updated : 22-10-2015

HGNC name	nuclear receptor subfamily 1, group H, member 2
HGNC id	7965

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to type 2 diabetes

Variant & Polymorphism SNP	two single nucleotide polymorphisms, LB44732G>A and rs2695121, were associated with obesity phenotypes
	common variation within the NR1H2 gene impaired insulin secretion, which may facilitate the development of type 2 diabetes

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

mice lacking Nr1h2, Nr1h3 manifested a breakdown in self-tolerance and developed autoantibodies and autoimmune glomerulonephritis