basic FUNCTION
| nuclear receptor, modulating gene activation by retinoic acid and thyroid hormone receptors |
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nuclear oxysterol receptors with established roles in cholesterol, lipid, and carbohydrate metabolism |
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required for the increase in adipocyte size that normally occurs with aging and diet-induced obesity, for adipocyte growth, glucose homeostasis, and beta cell function, and for expression of the cholesterol transporters, ABCA1 and ABCG1 |
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NR1H2, NR1H3 are negative regulators of cardiac growth and inflammation via suppressing NF-kappaB signalling in cardiomyocytes |
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induces the transcription of genes that protect cells from cholesterol overload |
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potential role in glucose metabolism in skeletal muscle |
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possible role as a transcriptional regulator in preeclampsia |
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NR1H2 and NR1H3 play a crucial role in control of insulin production and secretion in pancreatic beta-cells ( |
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potentially NR1H2 as well as NR1H3 could play a crucial role in the regulation of energy homeostasis |
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NR1H2, NR1H3 play central roles in the transcriptional control of lipid metabolism |
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can cause a post-translational response by binding directly to ABCA1, as well as a transcriptional response, to maintain cholesterol homeostasis |