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FLASH GENE

Symbol

MAP3K12

contributors: mct/npt - updated : 24-08-2012

HGNC name	mitogen-activated protein kinase kinase kinase 12
HGNC id	6851

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   MAP3K12 depletion interrupts progression of the cell cycle from the G1 to S phase

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed neuromuscular spinal muscular atrophy   could become a strategic therapeutic target in motor neuron diseases in which aberrant activation of the apoptogenic cascade is involved

ANIMAL & CELL MODELS

Map3k12-null mice displayed reduced apoptosis in multiple neuronal populations during development, demonstrating that prodegenerative Map3k12 signaling is required in vivo