basic FUNCTION
| serine/threonine protein kinase contributing in the developing brain to cytodifferentiation, apoptotic elimination, and migration |
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acting in the epidermis to promote the terminal differentiation of keratinocytes |
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acting as a signaling molecule implicated in the regulation of keratinocyte terminal differentiation and cornification |
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plays a significant role in the coordinated regulation of radial migration and axon projection by modulating JNK activity |
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potential role in PDGF signaling |
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potentially involved in regenerative responses of mammalian dorsal root ganglion neurons to axonal injury through activation of c-JUN |
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plays a significant role in the coordinated regulation of radial migration and axon projection by modulating JNK activity |
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key regulator of development, cell differentiation and apoptosis |
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critical role in naturally occurring programmed cell death of motoneurons |
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selectively regulates the JNK-based stress response pathway to mediate axon degeneration and neuronal apoptosis without influencing other aspects of JNK signaling |
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participates in cell proliferation and/or survival, at least in part, by modulating the expression of cell cycle regulatory proteins |
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appears to be important for proper cell proliferation and/or cell survival |
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cell cycle-regulated protein whose depletion by RNA interference causes proliferation arrest concomitantly with senescence |
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essential component of the neuronal response to axon damage, broadly regulating the transcriptional response to axonal injury |
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is required for both the proapoptotic and proregenerative responses that occur after optic nerve lesion through broad regulation of injury-induced alterations in gene expression |