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FLASH GENE

Symbol

MXI1

contributors: mct/npt/pgu - updated : 27-11-2013

HGNC name	MAX interactor 1
HGNC id	7534

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral somatic mutation       or deleted in prostate carcinoma   somatic mutation       in acute leukaemia constitutional     --over   represses renal epithelial cell tubulogenesis by suppressing MMP9 gene expression by functioning in activations of ERK and JNK constitutional     --over   resulted in a decrease in the PKD1, PKD2 and MYC mRNA relating to the pathway of cyst formation

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

lack of Mxi1 gene expression leads to cyst formation in Mxi1-deficient mice