protein
| interacting with Max to bind Myc-Max recognition E box sites through interaction between the N terminus and SIN3 corepressor |
|
is an important downstream target of HIF that contributes to VHL-deficient renal cancer tumorigenesis (PMID; |
|
inactivation of MXI1 has a positive effect on cell proliferation by down-regulating IGFBP3 |
|
antagonist of the MYC oncogene |
|
IGFBP3 is an important mediator of the MXI1-related proliferation mechanism |
|
Myc protein, which is antagonized by MXI1, causes renal cystogenesis |
|
its overexpression plays a role in the regulation of tubulogenesis by regulating some genes participating in renal epithelial branching tubulogenesis such as matrix metalloproteinase 9 (MMP9), integrins, fibronectin, and CDH1 |
|
MXI1 regulates IFT20 promoter activity via ETS1 binding to the IFT20 promoter |