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Symbol FUT2 contributors: mct - updated : 09-03-2016
HGNC name fucosyltransferase 2 (secretor status included)
HGNC id 4013
corresponding disease(s) H
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --other  
altered expression of fucosylation pathway gene(FUT2), correlated with poor survival in patients with non&8209;small cell lung cancer (NSCLC)
  • to variation of plasma vitamin B12 levels
  • to variation in progression of HIV-1 infection
  • to Crohn disease (CD)
  • to Norovirus Infections
  • to variation of human intestinal microbiota
  • to type 1 diabetes
  • to familial otitis media
  • to intestinal-type gastric cancer
  • Variant & Polymorphism SNP
  • association of four SNPs and CD
  • common variants of FUT2 are associated with plasma vitamin B12 levels
  • nonsense mutation 428G-->A in the FUT2 gene associated with a slow disease progression of HIV-1 infection
  • nonsecretor A/A genotype of rs601338A>G was found to confer susceptibility to type 1 diabetes
  • secretor status and FUT2 polymorphism are associated with the composition of human intestinal microbiota, and appears thus to be one of the key drivers affecting the individual variation of human intestinal microbiota
  • susceptibility to Norovirus infections influenced by FUT2 Genotype
  • common and rare FUT2 variants confer susceptibility to otitis media, likely by modifying the middle ear microbiome through regulation of A antigen levels in epithelial cells
  • variants (and haplotypes) in FUT2 (Se), FUT3 (Le) and FUT6 associated with intestinal-type gastric cancer
  • Candidate gene
    Marker could be useful to predict breast cancer axillary lymph nodes metastasis )
    Therapy target