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FLASH GENE
Symbol FUT2 contributors: mct - updated : 09-03-2016
HGNC name fucosyltransferase 2 (secretor status included)
HGNC id 4013
Corresponding disease
H Bombay phenotype
Location 19q13.33      Physical location : 49.199.227 - 49.209.190
Synonym name
  • alpha (1,2) fucosyltransferase
  • GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2
  • secretor blood group alpha-2-fucosyltransferase
  • alpha(1,2)FT2
    • Synonym symbol(s) SE, Se2, sej, SEC2, B12QTL1
    EC.number 2.4.1.69
    DNA
    TYPE functioning gene
    STRUCTURE 9.96 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    motif repetitive sequence
    text structure tetrameric short tandem repeat located in the 3prime flanking region
    MAPPING cloned Y linked Y status confirmed
    Map see FUT1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 3099 - 343 - 1995 7876234
    2 - 3089 - 343 - 1995 7876234
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivestomach   highly
    Lymphoid/Immunespleen   highly
    Reproductivemale systemtestis  moderately
    Respiratorylung   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscular    
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Fut2
    ortholog to rattus Fut2
    Homologene
    FAMILY
  • glycosyltransferase 11 family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text type II membrane protein; membrane-bound form in trans cisternae of Golgi
    basic FUNCTION
  • creating a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble A and B antigen
    • synthesis pathway
  • fucosyltransferase responsible for ABO biosynthesis in body fluids
  • fucosyltransferase required for the biosynthesis of the terminal glycan motif
  • novel role for FUT2 as a regulator of angiogenesis
  • catalyzes fucose addition to form H-type antigens in exocrine secretions
  • selection of mutualistic microorganisms of the intestinal microbiota is controlled by the FUT2 and FUT3 genes that encode fucosyltransferases, enzymes responsible for the synthesis of fucosylated glycan structures of mucins and milk oligosaccharides
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    glycosylation
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other macrophages regulate expression of FUT1, FUT2 genes in human endometrial epithelial cells
    ASSOCIATED DISORDERS
    corresponding disease(s) H
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    altered expression of fucosylation pathway gene(FUT2), correlated with poor survival in patients with non&8209;small cell lung cancer (NSCLC)
    Susceptibility
  • to variation of plasma vitamin B12 levels
  • to variation in progression of HIV-1 infection
  • to Crohn disease (CD)
  • to Norovirus Infections
  • to variation of human intestinal microbiota
  • to type 1 diabetes
  • to familial otitis media
  • to intestinal-type gastric cancer
    • Variant & Polymorphism SNP
  • association of four SNPs and CD
  • common variants of FUT2 are associated with plasma vitamin B12 levels
  • nonsense mutation 428G-->A in the FUT2 gene associated with a slow disease progression of HIV-1 infection
  • nonsecretor A/A genotype of rs601338A>G was found to confer susceptibility to type 1 diabetes
  • secretor status and FUT2 polymorphism are associated with the composition of human intestinal microbiota, and appears thus to be one of the key drivers affecting the individual variation of human intestinal microbiota
  • susceptibility to Norovirus infections influenced by FUT2 Genotype
  • common and rare FUT2 variants confer susceptibility to otitis media, likely by modifying the middle ear microbiome through regulation of A antigen levels in epithelial cells
  • variants (and haplotypes) in FUT2 (Se), FUT3 (Le) and FUT6 associated with intestinal-type gastric cancer
    • Candidate gene
    Marker could be useful to predict breast cancer axillary lymph nodes metastasis )
    Therapy target
    ANIMAL & CELL MODELS