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FLASH GENE
Symbol APLN contributors: mct/npt - updated : 16-04-2016
HGNC name apelin
HGNC id 16665
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --low  
in cardiac heart failure and coronary heart disease
constitutional     --over  
during adipocyte differentiation stage
constitutional     --over  
in hepatic cirrhosis (Principe 2008)
constitutional     --other  
might be involved in the mechanism of establishment of overt diabetes mellitus as well as associated atherosclerotic complications (Erdem 2008)
constitutional     --over  
in aortic valve stenosis, of the apelin-APLNR signaling pathway (Peltonen 2009)
constitutional     --low  
in women with polycystic ovary syndrome
constitutional     --over  
of APLN or APLNR promoted the hypoxia-induced proliferation of the Endothelial progenitor cells (EPCs)
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
diabetemetabolic syndrom 
autocrine signaling of apelin may serve as a novel therapeutic target for obesity and other metabolic disorders
obesity  
autocrine signaling of apelin may serve as a novel therapeutic target for obesity and other metabolic disorders
obesity  
blocking apelin signaling with anti-apelin antibodies will lead not only to inhibition of angiogenesis in adipose tissue but also to decreased adiposity
cardiovascularaquired 
apelin-APLNR signaling pathway, is a possible novel target for drug discovery in calcified aortic valve disease by suppressing chemotaxis, angiogenesis and osteoblast activity, all of which are well-documented phenomena in the disease process
digestiveliver 
hepatic apelin system is a novel therapeutic target in liver disease
ANIMAL & CELL MODELS