Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

CPSF1

contributors: mct - updated : 23-03-2020

HGNC name	cleavage and polyadenylation specific factor 1, 160kDa
HGNC id	2324

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

MYP27

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   in diabetic retinopathy (DR) tissues and retinal vascular endothelial cells &65288;HRVECs&65289; under high-glucose (HG) conditions tumoral     --low   depletion of CPSF1 suppressed cell viability, impaired colony formation ability, induced cell cycle arrest at G0/G1 phase and promoted cell apoptosis in ovarian cancer cells

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer reproductive ovary its depletion might serve as a potential therapeutic target for human ovarian cancer

ANIMAL & CELL MODELS