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FLASH GENE

Symbol

ALX4

contributors: mct/npt - updated : 25-04-2023

HGNC name	ALX homeobox 4
HGNC id	450

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

PFM1 , DEL11PP , FND2

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in breast cancer, duct carcinoma in situ (DCIS) or invasive ductal carcinoma (IDC) (Chang 2009) tumoral     --low   in breast cancer cell lines and tissues

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	is an independent prognostic factor in breast cancer
	serum free DNA test of methylation of the ALX4 gene promoter is a sensitive and specific method and it seems ALX4 has the potential of a clinically useful test for the early detection of colorectal cancer
Therapy target

ANIMAL & CELL MODELS

inactivation of Alx4 causes lacrimal gland aplasia in both human and mouse