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FLASH GENE
Symbol ALX4 contributors: mct/npt - updated : 20-02-2010
HGNC name ALX homeobox 4
HGNC id 450
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • helix-turn-helix DNA binding domain
  • mono polymer homomer , heteromer , polymer
    HOMOLOGY
    interspecies homolog to murine Alx4
    Homologene
    FAMILY
  • paired homeobox family (non HOX)
  • CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • involved in endochondral bone ossification
  • plays a critical role both in craniofacial development as in skin and hair follicle development (Kayserili 2009)
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    text skull development
    PATHWAY
    metabolism
    signaling
    a component
  • forming homo or hetero polymers with other ALXs
  • INTERACTION
    DNA binding to palindromic sequences
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PFM1 , DEL11PP , FND2
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in breast cancer, duct carcinoma in situ (DCIS) or invasive ductal carcinoma (IDC) (Chang 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS