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FLASH GENE
Symbol CD84 contributors: mct - updated : 16-02-2016
HGNC name CD84 molecule
HGNC id 1704
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four potential N linked
  • 29 potential O linked glycosylation sites
  • an ectodomain that is highly glycosylated,
  • a cytoplasmic tail containing 2 copies of an ITSM, which can be phosphorylated
    • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • immunoglobulin subtype
    • CATEGORY antigen
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • SLAMF1, CD48, CD84, CD244, LY9, SLAMF6, SLAMF7 play an essential and non-redundant role in the control of humoral immune responses
  • important immunomodulatory receptor with roles in cytotoxicity, humoral immunity, autoimmunity, cell survival, lymphocyte development, and cell adhesion
  • negatively regulates IgE high-affinity receptor signaling in human mast cells
  • natural killer T (NKT) cells and innate CD8(+) T cell development can be regulated in a SAP-dependent and -independent fashion by SLAMF receptors, in which SLAMF1, SLAMF6, and SLAMF8 affect development of NKT cells, and CD84, SLAMF7, and SLAMF8 affect the development of innate CD8(+) T cells
  • is dispensable for thrombus formation and stabilization, indicating that its deficiency may be functionally compensated by other receptors or that it may be important for platelet functions different from platelet-platelet interactions
  • central role for germinal center (GC) B cell-specific CD84 and SLAMF6 expression in maintaining B cell tolerance in GCs and in preventing autoimmunity
  • SLAMF1, CD84, and SLAMF6 are important negative regulators of humoral immune response, consistent with the notion that SLAM family receptors have dual functions in immune responses
    • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other dual regulation mechanism for platelet CD84 by simultaneous extra- and intracellular cleavage that may modulate platelet-platelet and platelet-immune cell interactions
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in Kawasaki disease (KD)coronary arteries in patients with acute and chronic arterial disease
    tumoral     --over  
    in CLL is an important survival mechanism that appears to be an early event in the pathogenesis of the disease
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    therapeutic strategies based on the blockade of the CD84-dependent survival pathway in Chronic lymphocytic leukemia (CLL)
    ANIMAL & CELL MODELS
  • Cd84(-/-) mice exhibited unaltered hemostatic function and arterial thrombus formation