Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol VAMP4 contributors: mct - updated : 26-06-2012
HGNC name vesicle-associated membrane protein 4
HGNC id 12645
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an amphipathic helix which may participate in coiled coil interactions
  • a C terminal hydrophobic domain predicted to serve as a membrane anchor
  • a di-leucine motif required for its localization and AP-1 binding
  • a cytoplasmic domain responsible its correct subcellular targeting
  • HOMOLOGY
    Homologene
    FAMILY
  • synaptobrevin, V-SNARE protein family
  • CATEGORY structural protein , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytosolic,vesicle
    text predominantly in the trans-Golgi network
    basic FUNCTION
  • soluble N-ethylmaleimide sensitive attachment protein receptor
  • role in trans-Golgi network to endosome transport
  • R-SNARE that has never been shown to participate in regulated exocytoses, therefore appears to be harboured in the membrane of enlargeosomes and to be a member of the machinery mediating their regulated exocytosis
  • v-SNARE that reside in various post-Golgi vesicular compartments
  • with other VAMPs, has differential membrane fusion capacities, and imply that with the exception of VAMP5, VAMPs are essentially redundant in mediating fusion with plasma membrane t-SNAREs
  • VAMP7 is involved in many fusion processes and thus plays a more general function in NK-cell activity than VAMP4
  • directs synaptic vesicles to a pool that selectively maintains asynchronous neurotransmission
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text vesicular trafficking
    PATHWAY
    metabolism
    signaling
    a component
  • complex between proteins on vesicle and target membranes
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with SLC2A4 (requirement for VAMP4 for the initial biosynthetic entry of SLC2A4 from the Golgi apparatus into the insulin-responsive vesicle compartment) (Williams 2008)
  • PICALM is able to sort VAMP4 and VAMP7, even though they have sorting signals for other clathrin adaptors
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS