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FLASH GENE
Symbol VAMP4 contributors: mct - updated : 26-06-2012
HGNC name vesicle-associated membrane protein 4
HGNC id 12645
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumcardiac  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an amphipathic helix which may participate in coiled coil interactions
  • a C terminal hydrophobic domain predicted to serve as a membrane anchor
  • a di-leucine motif required for its localization and AP-1 binding
  • a cytoplasmic domain responsible its correct subcellular targeting
  • HOMOLOGY
    Homologene
    FAMILY
  • synaptobrevin, V-SNARE protein family
  • CATEGORY structural protein , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytosolic,vesicle
    text predominantly in the trans-Golgi network
    basic FUNCTION
  • soluble N-ethylmaleimide sensitive attachment protein receptor
  • role in trans-Golgi network to endosome transport
  • R-SNARE that has never been shown to participate in regulated exocytoses, therefore appears to be harboured in the membrane of enlargeosomes and to be a member of the machinery mediating their regulated exocytosis
  • v-SNARE that reside in various post-Golgi vesicular compartments
  • with other VAMPs, has differential membrane fusion capacities, and imply that with the exception of VAMP5, VAMPs are essentially redundant in mediating fusion with plasma membrane t-SNAREs
  • VAMP7 is involved in many fusion processes and thus plays a more general function in NK-cell activity than VAMP4
  • directs synaptic vesicles to a pool that selectively maintains asynchronous neurotransmission
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text vesicular trafficking
    PATHWAY
    metabolism
    signaling
    a component
  • complex between proteins on vesicle and target membranes
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with SLC2A4 (requirement for VAMP4 for the initial biosynthetic entry of SLC2A4 from the Golgi apparatus into the insulin-responsive vesicle compartment) (Williams 2008)
  • PICALM is able to sort VAMP4 and VAMP7, even though they have sorting signals for other clathrin adaptors
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS