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FLASH GENE
Symbol TMOD2 contributors: mct - updated : 21-10-2016
HGNC name tropomodulin 2 (neuronal)
HGNC id 11872
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal tropomyosin binding domain
  • C terminal actin-binding domain, and C-terminal (LRR) domain, having roles in the formation of neurite-like processes
    • HOMOLOGY
    Homologene
    FAMILY
  • tropomodulin family
    • CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    text
  • appears largely cytoplasmic
  • TMOD1, TMOD2 and TMOD3 are associated with the cytoskeleton of non-muscle cells and their expression has distinct consequences on cell morphology
    • basic FUNCTION
  • major binding protein to brain tropomyosin
  • may be playing a role in behavior, learning, memory, and synaptic plasticity
  • TMOD1 and TMOD2 have mechanistically distinct inhibitory roles in neurite formation, likely mediated via different effects on F-actin dynamics and via differential localizations during early neuritogenesis
  • is an actin-capping protein that binds to the two tropomyosins (TM) at the pointed end of the actin filament to prevent further actin polymerization and depolymerization
  • TMOD1 is involved in neuronal differentiation for proper neurite formation and outgrowth, and TMOD2 inhibits these processes
  • is a protein that binds and caps the pointed ends of actin filaments in erythroid and nonerythoid cell types
  • TMOD1, TMOD2, TMOD3 regulates the length of actin filaments by capping the pointed ends in a tropomyosin (TM)-dependent manner
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS