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FLASH GENE

Symbol

TMOD2

contributors: mct - updated : 21-10-2016

HGNC name	tropomodulin 2 (neuronal)
HGNC id	11872

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	64.80 kb     10 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001142885 9 - 9078 NP_001136357 - 315 - 2004 15095301 NM_014548 10 - 9186 NP_055363 39 351 - 2004 15095301

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive salivary gland       highly Nervous brain         Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow     highly

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N terminal tropomyosin binding domain
	C terminal actin-binding domain, and C-terminal (LRR) domain, having roles in the formation of neurite-like processes

HOMOLOGY

Homologene

FAMILY

tropomodulin family

CATEGORY

motor/contractile

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton
text	appears largely cytoplasmic
	TMOD1, TMOD2 and TMOD3 are associated with the cytoskeleton of non-muscle cells and their expression has distinct consequences on cell morphology

basic FUNCTION	major binding protein to brain tropomyosin
	may be playing a role in behavior, learning, memory, and synaptic plasticity
	TMOD1 and TMOD2 have mechanistically distinct inhibitory roles in neurite formation, likely mediated via different effects on F-actin dynamics and via differential localizations during early neuritogenesis
	is an actin-capping protein that binds to the two tropomyosins (TM) at the pointed end of the actin filament to prevent further actin polymerization and depolymerization
	TMOD1 is involved in neuronal differentiation for proper neurite formation and outgrowth, and TMOD2 inhibits these processes
	is a protein that binds and caps the pointed ends of actin filaments in erythroid and nonerythoid cell types
	TMOD1, TMOD2, TMOD3 regulates the length of actin filaments by capping the pointed ends in a tropomyosin (TM)-dependent manner

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS