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FLASH GENE
Symbol DEC1 contributors: mct - updated : 11-12-2010
HGNC name deleted in esophageal cancer 1
HGNC id 23658
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY tumor suppressor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
basic FUNCTION
  • functioning as a tumor suppressor associated with esophageal cancer
  • myopepithelial cell marker, playing an important role in the process of natural suppression of tumor invasion as it is expressed specifically in myoepithelial cells, providing a cellular barrier for the spreading cancer cells
    • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    text negative regulation of cell proliferation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    significantly reduced in esophageal squamous cell carcinoma
    tumoral     --low  
    and tends to contribute to the migration ability of Head and Neck Squamous cell lines
    Susceptibility to squamous cell carcinoma of the head and neck
    Variant & Polymorphism other functional DEC1 promoter polymorphism -249T>C reduces risk of squamous cell carcinoma of the head and neck
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS