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FLASH GENE

Symbol

DEC1

contributors: mct - updated : 11-12-2010

HGNC name	deleted in esophageal cancer 1
HGNC id	23658

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	260.83 kb     8 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

Map	cen - D9S262 - [D9S155 - D9S177 ] - D9S170 - D9S154 - D9S258 - qter
Text	[DESGC1 ]

regionally located

located in a region commonly deleted in esophageal squamous cell carcinomas

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_017418 8 - 1251 NP_059114 - 70 - 2005 15580306

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain

cell lineage
cell lines	esophageal squamous cell carcinomas
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

CATEGORY

tumor suppressor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm

basic FUNCTION	functioning as a tumor suppressor associated with esophageal cancer
	myopepithelial cell marker, playing an important role in the process of natural suppression of tumor invasion as it is expressed specifically in myoepithelial cells, providing a cellular barrier for the spreading cancer cells

CELLULAR PROCESS	cell life, proliferation/growth

PHYSIOLOGICAL PROCESS

text	negative regulation of cell proliferation

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   significantly reduced in esophageal squamous cell carcinoma tumoral     --low   and tends to contribute to the migration ability of Head and Neck Squamous cell lines

Susceptibility

to squamous cell carcinoma of the head and neck

Variant & Polymorphism other	functional DEC1 promoter polymorphism -249T>C reduces risk of squamous cell carcinoma of the head and neck

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS