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FLASH GENE
Symbol IMPA2 contributors: mct - updated : 27-05-2014
HGNC name inositol(myo)-1(or 4)-monophosphatase 2
HGNC id 6051
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , dimer
HOMOLOGY
intraspecies homolog to IMPA1
Homologene
FAMILY inositol monophosphatase family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
basic FUNCTION
  • key enzyme of the phosphatidyl inositol signaling pathway
  • having intrinsic IMPase activity that is completely dependent on magnesium
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    phosphatidyl inositol signaling pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
    Mg++
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) FEB6
    Susceptibility
  • to schizophrenia and lately febrile seizures
  • to bipolar disorders
    • Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS