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FLASH GENE
Symbol IMPA2 contributors: mct - updated : 27-05-2014
HGNC name inositol(myo)-1(or 4)-monophosphatase 2
HGNC id 6051
DNA
TYPE like-sequence
SPECIAL FEATURE arranged in tandem
STRUCTURE 49.00 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
Binding site   transcription factor
text structure multiple potential binding sites for Sp1 and consensus motifs for AP2 and other transcription factors
MAPPING cloned Y linked   status confirmed
Map pter - D18S482 - IMPA2 - PTPN2 - D18S71 - cen
Authors Gene Map (98)
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland   highly
 stomach   highly
Nervousbrain   lowly
Reproductivefemale systemuteruscervix highly
Urinarykidney   highly
cells
SystemCellPubmedSpeciesStageRna symbol
NervousPurkinje cell
NervousPurkinje cell
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal, pregnancy
Text tissues, placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , dimer
HOMOLOGY
intraspecies homolog to IMPA1
Homologene
FAMILY inositol monophosphatase family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
basic FUNCTION
  • key enzyme of the phosphatidyl inositol signaling pathway
  • having intrinsic IMPase activity that is completely dependent on magnesium
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    phosphatidyl inositol signaling pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
    Mg++
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) FEB6
    Susceptibility
  • to schizophrenia and lately febrile seizures
  • to bipolar disorders
  • Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS