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FLASH GENE
Symbol COPB1 contributors: mct - updated : 15-10-2018
HGNC name coatomer protein complex, subunit beta 1
HGNC id 2231
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two globular domains interconnected by a flexible stalk domain like ADTB1 (CLAPB2)
  • HOMOLOGY
    intraspecies homolog to beta adaptin
    Homologene
    FAMILY
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    text colocalizing with GBF1 in a perinuclear structure
    basic FUNCTION
  • Golgi coatomer complex, component of the coat of the non clathrin-coated vesicle, involved in regulating membrane trafficking
  • plays a functional role in facilitating the transport of OPRK1 mRNAs into axons of dorsal root ganglia neurons
  • also plays a novel role in facilitating translation of OPRK1 mRNA in cortical neurons and enhances translation of proteins in the axonal compartment of dorsal root ganglia neurons
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • one of the seven subunits of COP1 coatomer complex or clathrin-binding complex that are known for transporting proteins among plasma membrane, trans-Golgi network, endoplasmic reticulum, and the lysosome/vacuole
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with the HIV.1 NeF protein
  • COPB1 negatively regulates ANO1 surface expression
  • CREB3 was identified as a transcriptional regulator of upregulated ER-Golgi trafficking genes ARF4, COPB1, and USO1, and silencing of these genes attenuated lung colonization in breast cancer
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS