Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

COPB1

contributors: mct - updated : 15-10-2018

HGNC name	coatomer protein complex, subunit beta 1
HGNC id	2231

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	11p15.2      Physical location : 14.479.048 - 14.521.441
Synonym name	beta coat protein
Synonym symbol(s)	COPB, FLJ10341

DNA

TYPE	functioning gene
STRUCTURE	42.00 kb     21 Exon(s)

MAPPING

cloned

Y

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001144061 21 - 3429 NP_001137533 - 953 - 2016 27207835 NM_001144062 21 - 3368 NP_001137534 - 953 - 2016 27207835 NM_016451 22 - 3490 NP_057535 - 953 - 2016 27207835

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive esophagus       highly Lymphoid/Immune thymus       highly Respiratory respiratory tract trachea     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

two globular domains interconnected by a flexible stalk domain like ADTB1 (CLAPB2)

HOMOLOGY

intraspecies

homolog to beta adaptin

Homologene

FAMILY

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,cytoplasm,organelle,Golgi
	intracellular,cytoplasm,cytosolic
text	colocalizing with GBF1 in a perinuclear structure

basic FUNCTION	Golgi coatomer complex, component of the coat of the non clathrin-coated vesicle, involved in regulating membrane trafficking
	plays a functional role in facilitating the transport of OPRK1 mRNAs into axons of dorsal root ganglia neurons
	also plays a novel role in facilitating translation of OPRK1 mRNA in cortical neurons and enhances translation of proteins in the axonal compartment of dorsal root ganglia neurons

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

one of the seven subunits of COP1 coatomer complex or clathrin-binding complex that are known for transporting proteins among plasma membrane, trans-Golgi network, endoplasmic reticulum, and the lysosome/vacuole

INTERACTION

DNA

RNA

small molecule

protein	interacting with the HIV.1 NeF protein
	COPB1 negatively regulates ANO1 surface expression
	CREB3 was identified as a transcriptional regulator of upregulated ER-Golgi trafficking genes ARF4, COPB1, and USO1, and silencing of these genes attenuated lung colonization in breast cancer

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS