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FLASH GENE
Symbol PPP1R9A contributors: mct/ - updated : 04-01-2012
HGNC name protein phosphatase 1, regulatory (inhibitor) subunit 9A
HGNC id 14946
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a SAM (sterile alpha motif) domain
  • a pDZ/HDR domain
  • actin and PP1 binding motifs
  • coiled-coil domains
    • mono polymer homomer , dimer , trimer , tetramer
    HOMOLOGY
    interspecies ortholog to rattus ppp1r9a (87 pc)
    Homologene
    FAMILY
    CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    text highly enriched in the dendritic spine
    basic FUNCTION
  • mediating protein-protein interactions
  • cross linking activity
  • involved in neurite formation
  • inhibiting protein phosphatase 1-alpha
  • PPP1R19A, and PPP1R19B reciprocally regulate Ca(2+) signaling by GPCRs
  • neuronal-specific F-actin-binding protein, having an essential function in the developing forebrain
  • important for spine morphogenesis and synaptic formation
  • contributes to hippocampal long-term potentiation and contextual fear memory
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component PPP1R9B/PPP1R9A forms a functional pair of opposing regulators that modulates Ca(2+) signaling intensity by GPCRs by determining the extent of inhibition by the R4 family of RGS proteins
  • scaffolding protein that interacts with actin and protein phosphatase-1
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • actin filaments (f.actin), PP1, neurabin II and p70-s6k
  • TGOLN2 interacts with the coiled coil region of neurabin and binds preferentially with the dimeric form of neurabin (neurabin provides a direct physical link between TGOLN2-containing membranes and the actin cytoskeleton)
  • CDK5, a key regulator of neuronal migration and morphology, directly phosphorylates PPP1R19A and controls its association with F-actin
    • cell & other
    REGULATION
    Phosphorylated by CDK5
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS