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FLASH GENE

Symbol

PPP1R9A

contributors: mct/ - updated : 04-01-2012

HGNC name	protein phosphatase 1, regulatory (inhibitor) subunit 9A
HGNC id	14946

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	388.78 kb     20 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001166161 18 splicing 10219 NP_001159633 43.1 387 - 2004 15286155 short form additionnal exon 12b to 12e,lacking exon 14 NM_001166160 20 splicing 10519 NP_001159632 - 1374 - 2004 15286155 NM_001166162 17 splicing 10090 NP_001159634 - 1253 - 2004 15286155 short form an alternative exon 12e NM_001166163 14 - 9601 NP_001159635 - 1090 - NM_017650 16 - 9705 NP_060120 - 1098 - -

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine neuroendocrine pituitary     highly   parathyroid       highly Nervous brain         Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron Nervous neuron Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

Text	embryonic skeletal muscle and other tissues

IMPRINTING	paternally
text	maternally expressed in embryonic skeletal muscle and tongue in eye and in extra -embryonic tissues

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a SAM (sterile alpha motif) domain
	a pDZ/HDR domain
	actin and PP1 binding motifs
	coiled-coil domains

mono polymer

homomer , dimer , trimer , tetramer

HOMOLOGY

interspecies

ortholog to rattus ppp1r9a (87 pc)

Homologene

FAMILY

CATEGORY

enzyme , regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
text	highly enriched in the dendritic spine

basic FUNCTION	mediating protein-protein interactions
	cross linking activity
	involved in neurite formation
	inhibiting protein phosphatase 1-alpha
	PPP1R19A, and PPP1R19B reciprocally regulate Ca(2+) signaling by GPCRs
	neuronal-specific F-actin-binding protein, having an essential function in the developing forebrain
	important for spine morphogenesis and synaptic formation
	contributes to hippocampal long-term potentiation and contextual fear memory

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	PPP1R9B/PPP1R9A forms a functional pair of opposing regulators that modulates Ca(2+) signaling intensity by GPCRs by determining the extent of inhibition by the R4 family of RGS proteins
	scaffolding protein that interacts with actin and protein phosphatase-1

INTERACTION

DNA

RNA

small molecule

protein	actin filaments (f.actin), PP1, neurabin II and p70-s6k
	TGOLN2 interacts with the coiled coil region of neurabin and binds preferentially with the dimeric form of neurabin (neurabin provides a direct physical link between TGOLN2-containing membranes and the actin cytoskeleton)
	CDK5, a key regulator of neuronal migration and morphology, directly phosphorylates PPP1R19A and controls its association with F-actin

cell & other

REGULATION

Phosphorylated by

CDK5

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS