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FLASH GENE
Symbol ARHGAP31 contributors: mct - updated : 01-06-2011
HGNC name Rho GTPase activating protein 31
HGNC id 29216
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to rattus Cdgap (79.8 pc)
homolog to murine Cdgap (79.4 pc)
intraspecies homolog to N chimerin 3
Homologene
FAMILY
CATEGORY unknown/unspecified
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic,granule
basic FUNCTION
  • a novel GAP that is likely to participate in Cdc42- and Rac-induced signaling pathways leading to actin reorganization
  • may play an unexpected role in apoptosis
  • CDC42/RAC1 regulatory protein, required during early human development
  • roles for ARHGAP30 and ARHGAP31 in regulation of cell adhesion downstream of RHOU
    • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • intersectin-SH3D/ARHGAP31 interaction (interacts directly with a small region of ARHGAP31 highly enriched in basic residues and comprising a novel conserved xKx(K/R)K motif)
  • ARHGAP30 and ARHGAP31 bind to one of the fourth SH3 domain of the endocytic protein intersectin through a novel type of motif
  • link between RHOU and the endocytic machinery via the ARHGAP30/ARHGAP31 subfamily of RhoGAP proteins
    • cell & other
    REGULATION
    induced by serum stimulation
    Other regulated and phosphorylated by GSK3A and GSK3B, (mechanism for cells to control Cdc42/Rac1 GTPase signaling pathways)
    ASSOCIATED DISORDERS
    corresponding disease(s) AOS
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS