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FLASH GENE

Symbol

ARHGAP31

contributors: mct - updated : 01-06-2011

HGNC name	Rho GTPase activating protein 31
HGNC id	29216

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	125.10 kb     12 Exon(s)

regulatory sequence

Binding site

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_020754 12 - 8096 157 1444 - 2007 17158447

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive mouth       moderately Endocrine neuroendocrine pituitary     highly Nervous nerve       highly

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text	predominantly in umbilical cord

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies	homolog to rattus Cdgap (79.8 pc)
	homolog to murine Cdgap (79.4 pc)

intraspecies

homolog to N chimerin 3

Homologene

FAMILY

CATEGORY

unknown/unspecified

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic,granule

basic FUNCTION	a novel GAP that is likely to participate in Cdc42- and Rac-induced signaling pathways leading to actin reorganization
	may play an unexpected role in apoptosis
	CDC42/RAC1 regulatory protein, required during early human development
	roles for ARHGAP30 and ARHGAP31 in regulation of cell adhesion downstream of RHOU

CELLULAR PROCESS	cell life, cell death/apoptosis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein	intersectin-SH3D/ARHGAP31 interaction (interacts directly with a small region of ARHGAP31 highly enriched in basic residues and comprising a novel conserved xKx(K/R)K motif)
	ARHGAP30 and ARHGAP31 bind to one of the fourth SH3 domain of the endocytic protein intersectin through a novel type of motif
	link between RHOU and the endocytic machinery via the ARHGAP30/ARHGAP31 subfamily of RhoGAP proteins

cell & other

REGULATION

induced by

serum stimulation

Other

regulated and phosphorylated by GSK3A and GSK3B, (mechanism for cells to control Cdc42/Rac1 GTPase signaling pathways)

ASSOCIATED DISORDERS

corresponding disease(s)

AOS

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS