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FLASH GENE
Symbol CSTF1 contributors: npt/mct - updated : 27/11/2008
HGNC name cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
HGNC id 2483
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a transducin repeat in which an approximately 44AA long sequence is repeated seven times
    • HOMOLOGY
    intraspecies homolog to G protein beta-subunit
    Homologene
    FAMILY
  • Trp-Asp (WD) repeat proteins proteins family
    • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • invoved in pre-RNA polyadenylation
  • required for the specific cleavage and polyadenylation of pre-mRNA
    • CELLULAR PROCESS nucleotide, transcription, maturation
    PHYSIOLOGICAL PROCESS
    text mRNA cleavage and processing
    PATHWAY
    metabolism
    signaling
    a component
  • component of the 3' pre-RNA polyadenylation complex
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • BARD1
  • interacting with the C terminal domain of RNA polymerase 2
  • with poly(A) polymerase (PAP) had no detectable effect on the binding of CPSF6
    • to pre-mRNA
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS