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FLASH GENE

Symbol

CSTF1

contributors: npt/mct - updated : 27/11/2008

HGNC name	cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
HGNC id	2483

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive esophagus       highly Endocrine adrenal gland       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal   highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a transducin repeat in which an approximately 44AA long sequence is repeated seven times

HOMOLOGY

intraspecies

homolog to G protein beta-subunit

Homologene

FAMILY

Trp-Asp (WD) repeat proteins proteins family

CATEGORY

RNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	invoved in pre-RNA polyadenylation
	required for the specific cleavage and polyadenylation of pre-mRNA

CELLULAR PROCESS

nucleotide, transcription, maturation

PHYSIOLOGICAL PROCESS

text	mRNA cleavage and processing

PATHWAY

metabolism

signaling

a component

component of the 3' pre-RNA polyadenylation complex

INTERACTION

DNA

RNA

small molecule

protein	BARD1
	interacting with the C terminal domain of RNA polymerase 2
	with poly(A) polymerase (PAP) had no detectable effect on the binding of CPSF6
	to pre-mRNA

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS