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FLASH GENE

Symbol

POLQ

contributors: - updated : 03-10-2007

HGNC name	polymerase (DNA directed), theta
HGNC id	9186

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N terminal ATP-binding motif
	three polymerase motifs A,B,C in the C terminal half
	three sequence insertions between conserved motifs in its catalytic site

HOMOLOGY

interspecies

homolog to Drosophila mus 308

Homologene

FAMILY

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,interspace
	intracellular,nucleus,nucleoplasm

basic FUNCTION	only known enzyme that efficiently carries out both the insertion and extension steps for bypass of apurinic sites, commonly formed as endogenous genomic lesions
	may have a specialized function in lymphocytes and its overexpression may contribute to tumor progression

CELLULAR PROCESS

nucleotide, replication

PHYSIOLOGICAL PROCESS

text	nuclear genome

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral       loss of function in sporadic tumors tumoral     --over   in lung, stomach, colon cancers

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS