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FLASH GENE
Symbol POLQ contributors: - updated : 03-10-2007
HGNC name polymerase (DNA directed), theta
HGNC id 9186
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Hearing/Equilibriumearinnercochlea highly
Respiratoryrespiratory tractlarynx  highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text predominantly expressed in primary lymphoid organs including the fetal liver, thymus and bone marrow
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal ATP-binding motif
  • three polymerase motifs A,B,C in the C terminal half
  • three sequence insertions between conserved motifs in its catalytic site
    • HOMOLOGY
    interspecies homolog to Drosophila mus 308
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,interspace
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • only known enzyme that efficiently carries out both the insertion and extension steps for bypass of apurinic sites, commonly formed as endogenous genomic lesions
  • may have a specialized function in lymphocytes and its overexpression may contribute to tumor progression
    • CELLULAR PROCESS nucleotide, replication
    PHYSIOLOGICAL PROCESS
    text nuclear genome
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       loss of function
    in sporadic tumors
    tumoral     --over  
    in lung, stomach, colon cancers
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS