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FLASH GENE
Symbol CACNA1I contributors: - updated : 21-08-2007
HGNC name calcium channel, voltage-dependent, alpha 1I subunit
HGNC id 1396
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 28 potential phosphorylation sites
  • each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4)
    • HOMOLOGY
    Homologene
    FAMILY calcium channel alpha-1 subunit family
    CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • calcium low activated (LVA) voltage-gated channel, T type
  • involved in pacing neuronal firing and producing network oscillations such as those that occurs during sleeep and epilepsy (potential drug target)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text
  • activated by small membrane depolarizations and can generate burst firing and pacemaker activity
    • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    Ca2+ binding
    protein binding to both CATSPER1 and CATSPER2 (modulate the function of the CACNA1I channel, which might be important in the regulation of sperm function)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS