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FLASH GENE
Symbol CACNA1I contributors: - updated : 21-08-2007
HGNC name calcium channel, voltage-dependent, alpha 1I subunit
HGNC id 1396
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinethyroid    
Nervousbrain   predominantly
 nerve    
 nervecranial nerve   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 28 potential phosphorylation sites
  • each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4)
  • HOMOLOGY
    Homologene
    FAMILY calcium channel alpha-1 subunit family
    CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • calcium low activated (LVA) voltage-gated channel, T type
  • involved in pacing neuronal firing and producing network oscillations such as those that occurs during sleeep and epilepsy (potential drug target)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text
  • activated by small membrane depolarizations and can generate burst firing and pacemaker activity
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    Ca2+ binding
    protein binding to both CATSPER1 and CATSPER2 (modulate the function of the CACNA1I channel, which might be important in the regulation of sperm function)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS