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FLASH GENE
Symbol BAIAP2 contributors: mct/npt/pgu - updated : 13-10-2017
HGNC name BAI1-associated protein 2
HGNC id 947
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal inverse-BAR (Bin-amphipysin-Rvs) domain (IRSp53/MIM homology domain [IMD])
  • internal SH3 domain interacting with the proline rich fragment of BAI1 and with DRPA, associating with actin regulatory proteins, including EPS8
  • a GUK domain
  • two WW (phosphoserine- or phosphothreonine binding) domains
  • multiple PDZ domains
  • a MIM homology domain (IMD) that bundles actin filaments and interacts with the small GTPase Rac
  • an internal SH3 domain that associates with actin regulatory proteins, including Eps8
  • HOMOLOGY
    interspecies homolog to murine Baiap2
    Homologene
    FAMILY
  • MAGUK (membrane-associted guanylase kinase homolog) family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text
  • colocalizing with BAI1
  • DIAPH1 and WASF2 synergize with BAIAP2 to form filopodia
  • basic FUNCTION
  • involved in neuronal growth-cone guidance
  • functioning as a insulin receptor tyrosine kinase substrate and may be having a role for insulin in the central nervous system
  • scaffold protein that bundles actin filaments and interacts with the small GTPase Rac
  • plays a role in filopodium dynamics by coupling actin elongation with membrane protrusion
  • having an unique role as transducer of signalling, linking the protruding membrane to the underlying actin cytoskeleton
  • BAIAP2 and PPP1R9B regulate localized RAC1 activation by TIAM1
  • key effector of CDC42 that couples the two events essential for filopodium formation, plasma membrane protrusion and actin dynamics
  • has been implicated in regulating the formation of filopodia
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text neuronal development
    PATHWAY
    metabolism
    signaling
    a component
  • formation of a NCKIPSD-BAIAP2 complex mediated through direct association of the proline-rich domain (PRD) of NCKIPSD with the SH3 domain of BAIAP2
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • BAI1
  • binding partner of LIN7B
  • IQSEC2 may play roles downstream of NMDA receptors through the interaction with multivalent PSD proteins such as BAIAP2 and DLG4
  • binding partner for KANK1, a kidney ankyrin repeat-containing protein that functions to suppress cell proliferation and regulate the actin cytoskeleton
  • binding partner of NCKIPSD
  • binds to 14-3-3 after phosphorylation in a region that lies between the CRIB and SH3 domains (association inhibiting binding of the BAIAP2 SH3 domain to proteins such as WAVE2 and EPS8 and also prevents Cdc42-GTP interaction)
  • two TIAM1-interacting proteins in fibroblasts, insulin receptor substrate protein 53 kDa (BAIAP2) and PPP1R9B
  • also interacts directly with WASF2 and DIAPH1 within filopodia
  • interaction with the proline-rich region of WASF2 is believed to mediate WASF2 activity downstream of RAC1
  • DIAPH1 and WASF2 are important SH3 domain partners of BAIAP2 involved in filopodial protrusion
  • TGFBR3 is a novel regulator of BAIAP2/WAS via CDC42 to regulate filopodial formation and cell adhesion
  • SH2B1 beta interacts with BAIAP2-containing complexes to increase the number of filopodia
  • cell & other
    REGULATION
    repressed by KANK1 (negatively regulates the formation of lamellipodia by inhibiting the interaction between Rac1 and BAIAP2)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to adulthood Attention-deficit/hyperactivity disorder (ADHD)
    Variant & Polymorphism other polymorphisms increasing the risk of adulthood ADHD
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS