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FLASH GENE
Symbol BAIAP2 contributors: mct/npt/pgu - updated : 13-10-2017
HGNC name BAI1-associated protein 2
HGNC id 947
Location 17q25.3      Physical location : 79.008.946 - 79.091.232
Synonym name
  • insulin receptor tyrosine kinase substrate p53
  • brain specific angiogenesis (BAI1) inhibitor-associated protein 2
  • fas ligand-associated factor 3
    • Synonym symbol(s) IRSP53, BAP2, IRS-58, FLAF3, IRSp53/58
    DNA
    TYPE functioning gene
    STRUCTURE 82.29 kb     15 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 splicing 3188 58 521 - 1999 10343108
    15 splicing 3352 58 520 ubiquitous 1999 10343108
    short 3'utr
    15 splicing 2894 60.9 552 - 1999 10343108
    14 - 3306 - 534 - 1999 10343108
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N-terminal inverse-BAR (Bin-amphipysin-Rvs) domain (IRSp53/MIM homology domain [IMD])
  • internal SH3 domain interacting with the proline rich fragment of BAI1 and with DRPA, associating with actin regulatory proteins, including EPS8
  • a GUK domain
  • two WW (phosphoserine- or phosphothreonine binding) domains
  • multiple PDZ domains
  • a MIM homology domain (IMD) that bundles actin filaments and interacts with the small GTPase Rac
  • an internal SH3 domain that associates with actin regulatory proteins, including Eps8
    • HOMOLOGY
    interspecies homolog to murine Baiap2
    Homologene
    FAMILY
  • MAGUK (membrane-associted guanylase kinase homolog) family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text
  • colocalizing with BAI1
  • DIAPH1 and WASF2 synergize with BAIAP2 to form filopodia
    • basic FUNCTION
  • involved in neuronal growth-cone guidance
  • functioning as a insulin receptor tyrosine kinase substrate and may be having a role for insulin in the central nervous system
  • scaffold protein that bundles actin filaments and interacts with the small GTPase Rac
  • plays a role in filopodium dynamics by coupling actin elongation with membrane protrusion
  • having an unique role as transducer of signalling, linking the protruding membrane to the underlying actin cytoskeleton
  • BAIAP2 and PPP1R9B regulate localized RAC1 activation by TIAM1
  • key effector of CDC42 that couples the two events essential for filopodium formation, plasma membrane protrusion and actin dynamics
  • has been implicated in regulating the formation of filopodia
  • MTSS2, MTSS1, BAIAP2 promote negative, concave curvature based on their ability to self-associate, having distinct functions in synapse formation and synaptic plasticity
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text neuronal development
    PATHWAY
    metabolism
    signaling
    a component
  • formation of a NCKIPSD-BAIAP2 complex mediated through direct association of the proline-rich domain (PRD) of NCKIPSD with the SH3 domain of BAIAP2
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • BAI1
  • binding partner of LIN7B
  • IQSEC2 may play roles downstream of NMDA receptors through the interaction with multivalent PSD proteins such as BAIAP2 and DLG4
  • binding partner for KANK1, a kidney ankyrin repeat-containing protein that functions to suppress cell proliferation and regulate the actin cytoskeleton
  • binding partner of NCKIPSD
  • binds to 14-3-3 after phosphorylation in a region that lies between the CRIB and SH3 domains (association inhibiting binding of the BAIAP2 SH3 domain to proteins such as WAVE2 and EPS8 and also prevents Cdc42-GTP interaction)
  • two TIAM1-interacting proteins in fibroblasts, insulin receptor substrate protein 53 kDa (BAIAP2) and PPP1R9B
  • also interacts directly with WASF2 and DIAPH1 within filopodia
  • interaction with the proline-rich region of WASF2 is believed to mediate WASF2 activity downstream of RAC1
  • DIAPH1 and WASF2 are important SH3 domain partners of BAIAP2 involved in filopodial protrusion
  • TGFBR3 is a novel regulator of BAIAP2/WAS via CDC42 to regulate filopodial formation and cell adhesion
  • SH2B1 beta interacts with BAIAP2-containing complexes to increase the number of filopodia
    • cell & other
    REGULATION
    repressed by KANK1 (negatively regulates the formation of lamellipodia by inhibiting the interaction between Rac1 and BAIAP2)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to adulthood Attention-deficit/hyperactivity disorder (ADHD)
    Variant & Polymorphism other polymorphisms increasing the risk of adulthood ADHD
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS