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FLASH GENE
Symbol ANXA9 contributors: mct - updated : 30-03-2016
HGNC name annexin A9
HGNC id 547
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a C terminal "core" region made of four repeats homolog to the endonexin fold but missing the calcium binding sites (4 internal repeat domains, each of which includes a type II calcium-binding site)
  • the third repeat with an insertion-deletion
    • HOMOLOGY
    intraspecies homolog to derived by duplication of annexin 1 and annexin 2
    Homologene
    FAMILY
  • annexin family
  • calcium-dependent phospholipid-binding protein family
    • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    text peripheral plasma membrane-soluble fraction
    basic FUNCTION
  • putative ion channel formed by the tetrad core
  • annexin, whose intracelluar activity is not subject to Ca(2+) regulation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text calcium ion channel
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, other,
  • Ca2+
  • phospholipid
    • protein
  • ANXA2, ANXA8, and ANXA9 interacted with proAREG and ADAM17 on the cell surface
  • ANXA2, ANXA8, ANXA9, play an essential role in the ADAM17-mediated ectodomain shedding of EGFR ligands
  • ANXA9 is a novel interacting partner for periplakin (PPL)N-terminus
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS