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FLASH GENE

Symbol

ANXA9

contributors: mct - updated : 30-03-2016

HGNC name	annexin A9
HGNC id	547

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	14.04 kb     14 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_003568 14 - 1843 NP_003559 38 345 - 2012 22841549

EXPRESSION

Type

expressed in	(based on citations)
organ(s)

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial barrier lining epidermis stratum basale   Homo sapiens

cell lineage
cell lines	hepatoma cell lines
fluid/secretion

at STAGE

physiological period

embryo, fetal

Text	mainly in undifferentiating tissues

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a C terminal "core" region made of four repeats homolog to the endonexin fold but missing the calcium binding sites (4 internal repeat domains, each of which includes a type II calcium-binding site)
	the third repeat with an insertion-deletion

HOMOLOGY

intraspecies

homolog to derived by duplication of annexin 1 and annexin 2

Homologene

FAMILY	annexin family
	calcium-dependent phospholipid-binding protein family

CATEGORY

transport channel

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane
	intracellular
	intracellular,cytoplasm,cytosolic
text	peripheral plasma membrane-soluble fraction

basic FUNCTION	putative ion channel formed by the tetrad core
	annexin, whose intracelluar activity is not subject to Ca(2+) regulation

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

text	calcium ion channel

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding, other,
	Ca2+
	phospholipid

protein	ANXA2, ANXA8, and ANXA9 interacted with proAREG and ADAM17 on the cell surface
	ANXA2, ANXA8, ANXA9, play an essential role in the ADAM17-mediated ectodomain shedding of EGFR ligands
	ANXA9 is a novel interacting partner for periplakin (PPL)N-terminus

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS