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FLASH GENE

Symbol

EOMES

contributors: mct/pgu - updated : 11-06-2015

HGNC name	eomesodermin homolog (Xenopus laevis)
HGNC id	3372

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a large N terminal DNA binding domain (T-box)
	a carbohydrate binding domain within the Eomes C-terminal region sufficient for transfer and important for gene activation

HOMOLOGY

interspecies

ortholog to murine T-bet

Homologene

FAMILY

TBR1, brachyury subfamily

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	involved in developmental regulation
	acting as a key regulator in the development of cell-mediated immunity
	involved in late neuronal development
	may helps effect a cellular response to a morphogen gradient
	important role for TFAP2C, SMARCA4, and EOMES in trophoblast stem cell self-renewal
	with CDX2, are regarded as the key transcription factors required for the establishment of a functional trophectoderm
	essential for epithelial-to-mesenchymal transition, mesoderm migration and specification of definitive endoderm during gastrulation
	controls interleukin-5 production in memory T helper 2 cells through inhibition of activity of the transcription factor GATA3
	transcription factors CDX2 and EOMES may play critical roles in induced trophoblast progenitor (iTP) cell generation
	TBX2, TBX3, TBX4, TBX5 and three members of TBX1 (TBX1, TBX15, TBX18), Brachyury (T) and Eomes (TBR2) are expressed in the developing limb

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

development

PATHWAY

metabolism

signaling

a component

forms a Complex with phosphorylated SMAD2 to activate several mesodermal genes

INTERACTION

DNA

RNA

small molecule

protein	interacts with SMAD2 and is capable of working in a non-cell autonomous manner via transfer of EOMES protein between adjacent embryonic cells
	TFAP2C directly regulated the basal progenitor fate determinants NEUROD4 and EOMES
	interact with the transcription factor GATA3, preventing GATA3 binding to the IL5 promoter
	IRF4 is required to suppress EOMES expression following CD8+ T-Cell activation
	POU3F2, POU3F3 influence multiple stages of neurogenesis by suppressing Notch effector HES5, and promoting the expression of proneural transcription factors EOMES and TBR1
	NFIL3 binds directly to the regulatory regions of both EOMES and ID2, promoting their transcription
	EOMES coordinates neurogenesis expansion and precise microcircuit assembly via PCDH19 in the mammalian cortex

cell & other

REGULATION

activated by

inhibition of ITK together with IL4 increases EOMES up-regulation

ASSOCIATED DISORDERS

corresponding disease(s)

MPAC

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional germinal mutation       polymicrogyria

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

mice lacking both transcription factors Eomesodermin (Eomes) and Tbx21 failed to develop NK cells